우경미 Kyung Mi Woo   교수 / D.D.S.， Ph.D.
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· Major : 치과분자약리학， 조직공학
· E-mail : kmwoo@snu.ac.kr
· Tel : 02-740-8652
· Laboratory : Bio-Inspired Tissue Engineering
Current Research Interests

본 연구실은 조직공학 스캐폴드 개발과 스캐폴드-세포 계면 연구를 수행하고 있습니다. 전기방사 나노섬유 세포외기질(ECM) 성상에 의한 세포의 거동을 연구합니다. 또한, 약물수송체와 3D 프린팅 스캐폴드를 제작하고, 이를 바탕으로 조직공학적 재생 연구와 임상 적용을 모색하고 있습니다.


주요 연구 내용

마이크로-, 나노-표면구조에 세포부착기질에 의한 세포 거동 조절
스캐폴드 및 바이오프린팅용 잉크 개발
치아 및 치주조직의 조직공학적 재생 연구

약물전달용 마이크로/나노 입자 개발

치과질환 동물모델 개발 및 중개연구
 

Research Methodology

세포 추출, 분리, 배양

DNA/RNA 추출; real time qPCR

ELISA; Western blot; immunostaining; imaging

전기방사; 3D 바이오프린팅
microCT; 조직학적 분석

동물실험

Publication / Patent
Rahman SU, Oh JH, Cho YD, Chung SH, Lee G, Baek JH, Ryoo HM, Woo KM. (2018) Fibrous topography-potentiated canonical Wnt signaling directs the odontoblastic differentiation of dental pulp-derived stem cells. ACS Appl Mater Interfaces. 10(21): 17526-17541. 
  • Yoo YJ, Oh JH, Zhang Q, Lee W, Woo KM. (2018) Dimethyloxalylglycine-embedded Poly(ε-caprolactone) Fiber Meshes Promote Odontoblastic Differentiation of Human Dental Pulp-derived Cells. J Endod. 44(1):98-103
    Zhang Q, Hwang JW, Oh JH, Park CH, Chung SH, Lee YS, Baek JH, Ryoo HM, Woo KM. (2017) Effects of the fibrous topography-mediated macrophage phenotype transition on the recruitment of mesenchymal stem cells: An in vivo study. Biomaterials 149:77-87.
    Rahman SU, Park CH, Baek JH, Ryoo HM, Woo KM. (2017) Fibrin-Enhanced Canonical Wnt Signaling Directs Plasminogen Expression in Cementoblasts. Int J Mol Sci. 18: 2380.
    Park CH, Oh JH, Jung HM, Choi Y, Rahman SU, Kim S, Kim TI, Shin HI, Lee YS, Yu FH, Baek JH, Ryoo HM, Woo KM. (2017) Effects of the incorporation of ε-aminocaproic acid/chitosan particles to fibrin on cementoblast differentiation and cementum regeneration. Acta Biomater. 61:134-143.
    Cha JK, Lim HC, Lee JS, Choi SH, Woo KM*, Jung UW*. (2017) Sinus augmentation using a histone deacetylase inhibitor in a calcium sulfate carrier in rabbit: A pilot study. J Biomed Mater Res B Appl Biomater. 105:1916-1923. (* co-corresponding)
    Zhang Q, Oh JH, Park CH, Baek JH, Ryoo HM, Woo KM. (2017) Effects of Dimethyloxalylglycine-Embedded Poly(ε-caprolactone) Fiber Meshes on Wound Healing in Diabetic Rats. ACS Appl Mater Interfaces. 9:7950-7963.
    Kim WJ, Kim BS, Cho YD, Yoon WJ, Baek JH, Woo KM, Ryoo HM. (2017) Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery. Biomaterials 122:154-162.
    Yoo YJ, Oh JH, Lee W, Woo KM. (2016) Regenerative Characteristics of Apical Papilla-derived Cells from Immature Teeth with Pulpal and Periapical Pathosis. J Endod. 42(11):1626-1632.
  • Woo KM, Jung HM, Oh JH, Rahman SU, Kim SM, Baek JH, Ryoo HM. (2015) Synergistic effects of dimethyloxalylglycine and butyrate incorporated into α-calcium sulfate on bone regeneration. Biomaterials. 39:1-14.
  • Rahman SU, Lee MS, Baek JH, Ryoo HM, Woo KM. (2014) The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization. PLoS One. 9(11):e112078.
  • Oh JH, Kim HJ, Kim TI, Woo KM. (2014) Comparative evaluation of the biological properties of fibrin for bone regeneration. BMB Rep. 47(2):110-4.
  • Kim TI, Han JE, Jung HM, Oh JH, Woo KM. (2013) Analysis of histone deacetylase inhibitor-induced responses in human periodontal ligament fibroblasts. Biotechnol Lett. 35(1):129-33.
  • Oh JH， Kim HJ， Kim TI， Baek JH， Ryoo HM， Woo KM. (2012) The effects of the modulation of the fibronectin-binding capacity of fibrin by thrombin on osteoblasts differentiation. Biomaterials. 33(16):4089-4099.
  • Lee W， Oh JH， Park JC， Shin HI， Baek JH， Ryoo HM， Woo KM. (2012) Performance of electrospun poly(ε-caprolactone) fiber meshes used with mineral trioxide aggregates in a pulp capping procedure. Acta Biomater. 8(8):2986-95.
  • Oh JH, Seo J, Yoon WJ, Cho JY, Baek JH, Ryoo HM, Woo KM. (2011) Suppression of Runx2 protein degradation by fibrous engineered matrix. Biomaterials. 32(25):5826-36.
  • Jung HM, Song GA, Lee YK, Baek JH, Ryoo HM, Kim GS, Choung PH, Woo KM. (2010) Modulation of the resorption and osteoconductivity of alpha-calcium sulfate by histone deacetylase inhibitors. Biomaterials. 31(1):29-37.
  • Woo KM， Yu B， Jung HM， Lee YK. Comparative evaluation of different crystal-structured calcium sulfates as bone-filling materials. (2009) J Biomed Mater Res B Appl Biomater. 91(2):545-54.
  • Woo KM， Chen VJ， Jung HM， Kim TI， Shin HI， Baek JH， Ryoo HM， Ma PX. (2009) Comparative evaluation of nanofibrous scaffolding for bone regeneration in critical-size calvarial defects. Tissue Eng Part A. 15(8):2155-62.
  • Lim JI， Yu B， Woo KM*， Lee YK*. (2008) Immobilization of TiO2 nanofibers on titanium plates for implant applications. Appl Surf Sci 255(5):2456-2460. (* corresponding authors)  
  • Yi T， Baek JH， Kim HJ， Choi MH， Seo SB， Ryoo HM， Kim GS， Woo KM. (2007) Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis. Exp Mol Med. 39(2):213-21.
  • Woo KM Seo J， Zhang R， Ma PX. (2007) Suppression of apoptosis by enhanced protein adsorption on polymer/hydroxyapatite composite scaffolds. Biomaterials. 28(16):2622-30.
  • Woo KM Jun JH， Chen VJ， Seo J， Baek JH， Ryoo HM， Kim GS， Somerman MJ， Ma PX. (2007) Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials. 28(2):335-43.
  • Woo KM, Chen VJ, Ma PX. (2003) Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res A. 67(2):531-7.