Yu Frank Hong Yu Frank Hong   부교수 / Ph.D.
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신경생물학
· Major : 신경과학， 이온수송생리학
· E-mail : frankyu@snu.ac.kr
· Tel : 02-740-8755
· Laboratory :
Current Research Interests

From secretions of salivary fluid in the mouth to sensations of pain， cold， taste and touch， ion transport proteins are central players in mediating these sensory and physiological functions. Ion channels and ion transporters are membrane proteins that regulate flow and balance of ions between the cytosolic and extracellular fluids.  They are involved in cellular signaling and homeostasis in addition to the diverse array of integrative functions from epithelial transport of ions to neuronal electrical signaling to maintaining the basal electrical rhythms of the heart. 

My laboratory studies few selected members of ion transport proteins involved in neuronal and excitable cell signaling and pH and ion homeostasis related to salivary secretion.

1. Voltage-gated sodium channel NaV1.1 channelopathy: Severe Myoclonic Epilepsy in Infancy (SMEI).

2. Structure and function of voltage-gated sodium channel signaling complex

3. Ion transport mechanism in salivary secretion – pH， bicarbonate， chloride， water

Research Methodology
1. molecular biology， cell culture and transfection， protein biochemistry， ion transport assays and electrophysiology. 2. transgenic mouse technology R11; transgenic， constitutive and conditional knockout/knockin mouse models
Publication / Patent
Kalume F， Yu FH， Westenbroek RE， Scheuer T， Catterall WA (2007) Reduced sodium current in Purkinje neurons from NaV1.1(-/-) mice: Implications for ataxia in severe myoclonic epilepsy in infancy. J Neurosci， 27(41): 11065-74 . Yu FH， Mantegazza M， Westenbroek RE， Robbins CA， Kalume F， Spain W， Burton KA， McKnight GS， Scheuer T， Catterall WA (2006) Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy Nat Neurosci 9:1141-49 . Chen Y， Yu FH， Surmeier DJ， Scheuer T， Catterall WA (2006) Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C. Neuron 49:409-20 Yu FH， Catterall WA (2004) The VGL-chanome: A protein superfamily specialized for electrical signaling and ion homeostasis. Sci STKE 253: re15 .