박주철 Joo-Cheol Park   교수 / D.D.S.， Ph.D.
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세포 및 발생생물학 / 구강조직-발생생물학교실
· Major : 구강조직학(치아 발생 및 재생)
· E-mail : jcapark@snu.ac.kr
· Tel : 02-880-2335
· Laboratory : 구강조직발생학 연구실
Current Research Interests

최근 구강건강에 대한 관심이 증가함에 따라 치아 유지 욕구도 더욱 증대되고 있다. 손상된 치아의 재생은 치아의 전체 재생과 부분 재생으로 나눌 수 있는데, 본 실험실은 일차적으로는 치아의 상아질-치수 및 치주조직을 형성하는 세포들의 분화조절을 통하여 궁극적으로 손상된 치아와 치아주위조직을 재생함을 목표로 한다. 
          
치아 발생과정의 연구를 기반으로 상아질과 치주조직을 형성하는 상아모세포와 백악모세포의 분화, 치수및 치낭줄기세포를 이용한 상아질-치수와 치주조직의 재생, 치수-치낭줄기세포의 선택적 분화조절, 치주질환의 발생과 진행 및 골세포의 분화조절 등을 세포생물학적 및 분자생물학적 방법으로 연구하고 있다

Research Methodology

1. 상아모세포의 분화 조절 및 상아질 재생

  : PA-CM과 Copine7을이용한 치수줄기세포의 분화조절

  : Copine7을 단백질을 이용한 상아질의 재생과 상아질 지각과민증 치료 기술 개발

  : Copine7을 단백질의 세포내 작용기전 및 조절 인자 연구

2. 치주조직의 재생 및 치주질환의 병인론

  : 상피-간엽 상호작용을 이용한 치주조직 재생 연구

  : 바이오마커 ODAM을 이용한 치주질환과 임플란트주위염의 조기진단

3. Nuclear factor I-C를 이용한 골다공증 관련 연구

  : NFI-C에 의한 치아줄기세포의 stemness 조절

Publication / Patent

  1. Choung HW, Lee J-H, Shon WJ, Lee JH, Y. Ku, ParkJC. Tertiary dentin formation after indirect pulp capping using protein CPNE7. J Dent Res. 95(8):906-912, 2016.

  2. Lee HK, Park JW, Seo YM, Kim HH, Lee G, Bae HS, Park JC. Odontoblastic inductive potential of epithelial cells derived from human deciduous dental pulp. J Mol Histol. 47:345-351, 2016.

  3. Cho YD, Bae HS, Lee DS, Yoon YJ, Woo KM, Baek JH, Lee G, Park JC, Ku Y, Ryoo HM. Epigenetic priming confers direct cell trans-differentiation from Adipocyte to osteoblast in a transgene-free state. J Cell Physiol. 231(7):1484-1494, 2016.

  4. Yu SJ, Lee DS, Kim BO, Choi SH, Park JC. Periodontal healing with a preameloblast-conditioned medium in dogs. J Periodontal Res. 51:284-294, 2016.

  5. Choung HW, Lee DS, Lee HK, Son WJ, Park JC. Preameloblast-derived factors mediate osteoblast differentiation of human bone marrow mesenchymal stem cells via Runx2-Osterix-BSP signaling. Tissue Eng Part A. 22:93-102, 2016.

  6. Har A and Park JC. Dental stem cells and their applications. Chin J Dent Res. 18(4):207-12. 2015

  7. Lee HK and Park JC. Odontogenic Ameloblast-Associated Protein (Odam) plays crucial roles in osteoclast differentiation via control of actin ring formation. J Korean Dent Sci. 8(2):74-81, 2015.

  8. Lee HK, Choung HW, Yang YI, Yoon HJ, Park IA, Park JC. ODAM inhibits RhoA-dependent invasion in breast cancer. Cell Biochem Funct. 33(7):451-61. 2015

  9. Kim TH, Bae CH, Yang S, Park JC, Cho ES. Nfic regulates tooth root patterning and growth. Anat Cell Biol 48:188-194, 2015

  10. Yu SJ, Lee JS, Jung UW, Park JC, Kim BO, Choi SH. Effect of fibroblast growth factor on injured periodontal ligament and cementum after tooth replantation in dogs. J Periodontal Implant Sci. 45(3):111-119, 2015.

  11. Sey men F, Park JC, Lee KE, Lee HK, Lee DS, Koruyucu M, Gencay K, Bayram M, Tuna EB, Lee ZH, Kim YJ, Kim JW. Novel MMP20 and KLK4 mutations in amelogenesis imperfecta. J Dent Res. 94(8):1063-1069. 2015.

  12. Lee HK, Ji S, Park SJ, Choung HW, Choi Y, Lee HJ, Park SY, Park JC. Odontogenic ameloblast-associated protein (ODAM) mediates junctional epithelium attachment to teeth via integrin-ODAM-Rho guanine nucleotide exchange factor 5 (ARHGEF5)-RhoA signaling. J Biol Chem 290(23):14740-14753, 2015.

  13. Lee HK, Lee DS, Park JC. Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer. BMC Cancer 15:113, 2015.

  14. Park SJ, Bae HS, Park JC. Osteogenic differentiation and gene expression profile of human dental follicle cells induced by human dental pulp cells. J Mol Histol 46(1):93-106, 2015.

  15. Oh HJ, Choung HW, Lee HK, Park SJ, Lee JH, Lee DS, Seo BM, Park JC. CPNE7, a preameloblast-derived factor, regulates odontoblastic differentiation of mesenchymal stem cells. Biomaterials 37:208-217, 2015.

  16. Yun PY, Kim YK, Jeong KI, Park JC, Choi YJ. Influence of bone morphogenetic protein and proportion of hydroxyapatite on new bone formation in biphasic calcium phosphate graft: two pilot studies in animal bony defect model. J Craniomaxillofac Surg 42(8):1909-1917, 2014.

  17. Lee HK, Lee DS, Park SJ, Cho KH, Bae HS, Park JC. Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein (DSPP) and E-cadherin via control of Krüppel-like factor 4 (KLF4) during dentinogenesis. J Biol Chem 289:28225-28236, 2014.

  18. Nam H, Kim JH, Kim JW, Seo BM, Park JC, Kim JW, Lee G. Establishment of Hertwig's Epithelial Root Sheath/Epithelial Rests of Malassez cell line from human periodontium. Mol Cells 37(7):562-567, 2014.

  19. Lee DS, Choung HW, Kim HJ, Gronostajski RM, Yang YI, Ryoo HM, Lee ZH, Kim HH,Cho ES, Park JC. NFI-C regulates osteoblast differentiation via control of Osterix expression. Stem Cells 32:2467-2479, 2014.

  20. Kim J-S, Park M-G, Lee SA, Park S-Y, Kim HJ, Yu SK, Kim CS, Kim SG, Oh JS, You JS, Kim JS, S YS, Chun HS, Park JC, Kim DK. Downregulation of adenomatous polyposis coli by microRNA-663 promotes odontogenic differentiation through activation of Wnt/beta-catenin. Biochem Biophys Res Commun 446:894-900, 2014.

  21. Yoo YJ, Lee WC, Cho YA, Park JC, Shon WJ, Baek SH. Effect of conditioned medium from preameloblast on regenerative cellular differentiation of the immature teeth with necrotic pulp and apical periodontitis. J Endod 40 (9): 1355-1361, 2014.

  22. Park MG, Kim JS, Park SU, Lee SA, Kim HJ, Kim CS, Kim JS, Chun HS, Park JC, Kim DK. MicroRNA-27 promotes the differentiation of odontoblastic cell by targeting APC and activating Wnt/β-catenin signaling. Gene 538:266-272, 2014.